Dark DNA and the New Mechanism of Evolution?

Here is an article on the issue of Dark DNA.

Dark DNA got its name from the cosmological phenomenon called Dark Matter – the undetectable 25% of the mass of the universe that scientists know exists because they can detect its effects…

Similarly Dark DNA has eluded the sequencing of the genomes and yet scientists know it must exist because they see its effects, such as in case of the sand rat…

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Defending the validity and significance of the new theorem “Fundamental Theorem of Natural Selection With Mutations, Part II: Our Mutation-Selection Model

Defending the validity and significance of the new theorem “Fundamental Theorem of Natural Selection With Mutations, Part II: Our Mutation-Selection Model

– Bill Basener and John Sanford

Joe Felsenstein and Michael Lynch (JF and ML) wrote a blog post, “Does Basener and Sanford’s model of mutation vs selection show that deleterious mutations are unstoppable?”  Their post is thoughtful and we are glad to continue the dialogue. We previously wrote a first part of a response to their post, focusing on the impact of R. A. Fisher’s work.  This is the second part of our response, focusing on the modelling and mathematics.  Our paper can be found at: https://link.springer.com/article/10.1007/s00285-017-1190-x Continue reading

Natural Selection – Evolution Magic

Natural Selection is described as “the differential survival and reproduction of individuals due to differences in phenotype”. To this, some add “blind, mindless, and purposeless environmental process” that nonetheless is imagined turning random genetic mutations into superior new features enhancing descendants’ survivability (fitness). Accumulation of these features supposedly turns one lifeform into another over time. Natural Selection seeks to explain the appearance of design in nature without appealing to a designer. Continue reading

Defending the validity and significance of the new theorem “Fundamental Theorem of Natural Selection With Mutations, Part I: Fisher’s Impact

– Bill Basener and John Sanford

 

Joe Felsenstein and Michael Lynch (JF and ML) wrote a blog post, “Does Basener and Sanford’s model of mutation vs selection show that deleterious mutations are unstoppable?”  Their post is thoughtful and we are glad to continue the dialogue. This is the first part of a response to their post, focusing on the impact of R. A. Fisher’s work.  Our paper can be found at: https://link.springer.com/article/10.1007/s00285-017-1190-x

First, a short background on our paper:

The primary thesis of our paper is that Fisher was wrong, in a fundamental way, in his belief that his theorem (“The Fundamental Theorem of Natural Selection”), implied the certainty of ongoing fitness increase. His claim was that mutations continually provide variance, and selection turns the variance into fitness increase.  Central to his logic was that collectively; mutations have a net zero effect on fitness.  While Fisher assumed mutations are collectively fitness-neutral, it is now known that the vast majority of mutations are deleterious. So mutations can potentially push fitness down – even in the presence of selection. Continue reading

1. Evolution or Design? Duons

Have you ever tried writing palindromes? How about writing phrases that can be read the same way in either direction? Here are some examples:
A man, a plan, a canal: Panama
Live not on evil
Was it a car or a cat I saw
These sentences were no doubt designed…
Can you imagine writing a book that can be read forwards and backwards containing 2 different stories that made sense? Not an easy task…

Watch the video and pay special attention to the following examples:

  1. Alternative splicing of RNA that produces multiple proteins from one gene
  2. Duons – Overlapping sequences that code for both protein expression and transcription factor binding sites simultaneously
  3. Dual coding genes in which one sequence is read in multiple frames to produce completely different protein

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To Basener and Sanford: This is the 21st Century

What is The Skeptical Zone, William Basener and John Sanford? Why should you care?

The Skeptical Zone is where a couple of distinguished biologists, Joe Felsenstein and Michael Lynch, have dignified a recently published article of yours with a response. That is all you need to know. If they had responded on the back of a cereal box instead, providing you with a form to clip, then it would have behooved you to clip the form, fill it out, and send it, along with a self-addressed, stamped envelope, to their post office box in Battle Creek, Michigan.

Of course, I am dating myself — and also you. That is just the point. You ought to know that, even as the computer enables studies that were impossible when Ronald Fisher dubbed a not-so-fundamental result of his the Fundamental Theorem of Natural Selection, it enables interaction with domain experts in ways that were impossible in Fisher’s time. We are well into the 21st Century, and no one under the age of 50 will find credible any reason you might offer for declining to engage Joe in this forum. You can ignore all of the riff-raff, myself included, and interact with the scientist who happened, about the time that your paper addressing Fisher’s theorem was published, to address the theorem in the 37th Fisher Memorial Lecture (via video link, I might add).

The prospects for resolving some points, and arriving at a degree of agreement, are much better in a modern exchange of comments than in an old-fashioned exchange of essays. One aspect of The Skeptical Zone makes it particularly appealing in discussion of mathematical models: you can enter stuff like \LaTeX between two dollar signs, and cause readers to see stuff like \LaTeX. It’s a miracle!

Does Basener and Sanford’s model of mutation versus selection show that deleterious mutations are unstoppable?

by Joe Felsenstein and Michael Lynch

The blogs of creationists and advocates of ID have been abuzz lately about exciting new work by William Basener and John Sanford. In a peer-reviewed paper at Journal of Mathematical Biology, they have presented a mathematical model of mutation and natural selection in a haploid population, and they find in one realistic case that natural selection is unable to prevent the continual decline of fitness. This is presented as correcting R.A. Fisher’s 1930 “Fundamental Theorem of Natural Selection”, which they argue is the basis for all subsequent theory in population genetics. The blog postings on that will be found here, here, here, here, here, here, and here.

One of us (JF) has argued at The Skeptical Zone that they have misread the literature on population genetics. The theory of mutation and natural selection developed during the 1920s, was relatively fully developed before Fisher’s 1930 book. Fisher’s FTNS has been difficult to understand, and subsequent work has not depended on it. But that still leaves us with the issue of whether the B and S simulations show some startling behavior, with deleterious mutations seemingly unable to be prevented from continually rising in frequency. Let’s take a closer look at their simulations.

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Does all of evolutionary theory rest on Fisher’s Fundamental Theorem?

The blogs of creationists and ID advocates have been buzzing with the news that a new paper by William Basener and John Sanford, in Journal of Mathematical Biology, shows that natural selection will not lead to the increase of fitness. Some of the blog reports will be found here, here, here, here, here, and here. Sal Cordova has been quoting the paper at length in a comment here.

Basener and Sanford argue that the Fundamental Theorem of Natural Selection, put forward by R.A. Fisher in his book The Genetical Theory of Natural Selection in 1930, was the main foundation of the Modern Evolutionary Synthesis of the 1930s and 1940s. And that when mutation is added to the evolutionary forces modeled by that theorem, it can be shown that fitnesses typically decline rather than increase. They argue that Fisher expected increase of fitness to be typical (they call this Fisher’s Theorem”).

I’m going to argue here that this is a wrong reading of the history of theoretical population genetics and of the history of the Modern Synthesis. In a separate post, in a few days at Panda’s Thumb, I will argue that Basener and Sanford’s computer simulation has a fatal flaw that makes its behavior quite atypical of evolutionary processes.

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Fisher’s not-so-fundamental theorem

Congratulations to our resident theoretical biologist of high renown, Joe Felsenstein, on his presentation, yesterday, of the 37th Fisher Memorial Lecture. [ETA: I’ll post a separate announcement of the video, when it is released.] Following are the details provided by the Fisher Memorial Trust (with a link added by me).

Title: Is there a more fundamental theorem of natural selection?

Abstract. R.A. Fisher’s Fundamental Theorem of Natural Selection has intrigued evolutionary biologists, who wondered whether it could be the basis of a general maximum principle for mean fitness of the population. Subsequent work by Warren Ewens, Anthony Edwards, and George Price showed that a reasonable version of the FTNS is true, but only if the quantity being increased by natural selection is not the mean fitness of the population but a more indirectly defined quantity. That leaves us in an unsatisfactory state. In spite of Fisher’s assertion that the theorem “hold[s] the supreme position among the biological sciences”, the Fundamental Theorem is, alas, not-so-fundamental. There is also the problem that the additive genetic variances involved do not change in an easily predictable way. Nevertheless, the FTNS is an early, and imaginative, attempt at formulating macro-scale laws from population-genetic principles. I will not attempt to revive the FTNS, but instead am trying to extend a 1978 model of mine, put forth in what may be my least-cited paper. This attempts to make a “toy” model of an evolving population in which we can bookkeep energy flows through an evolving population, and derive a long-term prediction for change of the energy content of the system. It may be possible to connect these predictions to the rate of increase of the adaptive information (the “specified information”) embodied in the genetic information in the organisms. The models are somewhat absurdly oversimple, but I argue that models like this at least can give us some results, which decades of more handwavy papers on the general connection between evolution, entropy, and information have not.

Phylogenetic Systematics

Let’s have a serious discussion about phylogenetic systematics.

What are the assumptions, the methods, and the inferences that can be drawn from phylogenetic analysis.

For example, is there anything to the creationist claim that phylogenetic systematics assumes common ancestry and does it even matter?

I’ll be using a number of different references such as Molecular Evolution: A Phylogenetic Approach and Molecular Evolution and Phylogenetics.

This thread will not be password protected, but it will be protected by angels.

The Half-Truth of Darwinism, a Personal Opinion

Darwinism is incomplete because it only takes account of matter and ignores spirit.

Evolution is a process of matter ascending and spirit descending. It is a process whereby physical substance goes through process that prepares it to accommodate the descending spirit. The continuity of living matter is sustained by hereditary and it takes on various forms due to adaptive radiation. But these forces come from the earth and they tie organisms to the environment and lead only to specialization. They take organisms down ever narrowing paths. The fossil record is a tableau of forms that are frozen in their specializations, evolutionary dead ends. These earthly forces radiate from the centre.

The spiritual forces work in the opposite direction drawing the living substance outwards, emancipating it from the earthly forces. Through these forces organisms separate out from the earth as a plant grows towards the sun. Emancipation is evident in such things as inner temperature control, freeing of the upper limbs to perform creative functions rather than them being used for locomotion or support and taking responsibility for care of offspring.

It is only in the human form that the self-conscious ego can occupy physical substance as a material individual. This is the place on earth where matter and spirit meet. In as much as each of us know ourselves, we know the spirit within. And this is only possible because our form has been prepared in such a way that it can accommodate our ego, the spirit within.

Defining Fitness

There is a pretty interesting discussion going on in Noyau regarding the many definitions of “fitness” in evolutionary biology. It would be a shame for it to be lost in that particular venue here at TSZ. At the risk of being censored by the admins for posting too many OPs in one month I thought I’d start this thread.

Here’s my take so far:

Allan Miller was charged by phoodoo with resorting to different definitions of fitness. Allan denied the charge and when asked for a definition of fitness Allan provided one. Allan later stated that his definition only properly applied to asexual species.

Others chimed in to say that the definition of fitness depends on the context, which hardly seems to contradict what phoodoo was saying.

My own position is that fitness has its definition within a particular mathematical framework. My position is also that fitness can be defined generically but that such a definition is tautological. Special definitions of fitness are required to make the concept testable.

Here’s hoping we can move the discussion about fitness out of Noyau.

Five Questions Everyone Should Ask about Common Descent

I received my copy of Theistic Evolution today. The book contains three chapters dedicated to skepticism of universal common ancestry. As common descent seems to be a hot topic here lately I thought I’d read those chapters first and offer comments and invite responses.

I’ll start with Chapter 12, authored by Paul Nelson, which carries the title: Five Questions Everyone Should Ask about Common Descent. The five questions are as follows:

1. If species were not connected by common descent, how would we know it?
2. What were the actual transformation pathways, satisfying the continuity rule, which connect all organisms to LUCA?
3. Have we genuinely tested UCD, or merely assumed its truth?
4. When explaining the history of life, have we assumed methodological naturalism only, or have we allowed for the possibility of intelligent design?
5. In the light of intelligent design as a causal possibility, what histories for life on earth might be the case?

As usual, I don’t expect anyone else here to actually read this book because, you know, it just isn’t skeptical enough.

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Why Evolution Matters

Because evolution proves that God does not exist. Except when it doesn’t.

In June 2004, the science historian Frank Sulloway and I began a month-long expedition to retrace Charles Darwin’s footsteps in the Galápagos Islands. It turned out to be one of the most physically grueling experiences of my life…

– Shermer, Michael. Why Darwin Matters: The Case Against Intelligent Design.

Just like taking a pilgrimage. All hail Darwin.

Any other Darwin worshipers here who have taken the Darwin pilgrimage?

What motivated you to try to retrace the footsteps of your master?

The Anti-Synthesis

Why we don’t want another “Synthesis”

High-level debates in evolutionary biology often treat the Modern Synthesis as a framework of population genetics, or as an intellectual lineage with a changing distribution of beliefs. Unfortunately, these flexible notions, used to negotiate decades of innovations, are now thoroughly detached from their historical roots in the original Modern Synthesis (OMS), a falsifiable scientific theory.

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Common Design vs. Common Descent

I promised John Harshman for several months that I would start a discussion about common design vs. common descent, and I’d like to keep my word to him as best as possible.

Strictly the speaking common design and common descent aren’t mutually exclusive, but if one invokes the possibility of recent special creation of all life, the two being mutually exclusive would be inevitable.

If one believes in a young fossil record (YFR) and thus likely believes life is young and therefore recently created, then one is a Young Life Creationist (YLC). YEC (young earth creationists) are automatically YLCs but there are a few YLCs who believe the Earth is old. So evidence in favor of YFR is evidence in favor of common design over common descent.

One can assume for the sake of argument the mainstream geological timelines of billions of years on planet Earth. If that is the case, special creation would have to happen likely in a progressive manner. I believe Stephen Meyer and many of the original ID proponents like Walter Bradley were progressive creationists.
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The Mystery of Evolution: 10. Falsifying the Evolution-The Experiment #1

I have promised that I will try to falsify the evolutionary theory by performing some simple experiments, as many of Darwin’s faithful on this blog have been really reluctant to do or even to suggest such an experiment…

However, one video was posted on TSZ suggesting that such an experiment has already been performed by Biologist Ken Dial in a study of how young birds use their developing wings that is supposed shed light on the evolution of flight in birds.

The Origin of Flight–What Use is Half a Wing? | HHMI BioInteractive Video


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Purpose and Desire

Purpose and Desire: What Makes Something “Alive” and Why Modern Darwinism Has Failed to Explain It is the new book by physiologist J. Scott Turner, author of The Tinkerer’s Accomplice: How Design Emerges from Life Itself.

The book may make some “skeptics” uncomfortable, but maybe they should read it anyways.

From the book:

I have come to believe that there is something presently wrong with how we scientists think about life, its existence, its origins, and its evolution.

Without a coherent theory of life, whatever we think about life doesn’t hold water. This applies to the major contribution we claim that the modern science of life offers to the popular culture: Darwinism.

… there sits at the heart of modern Darwinism an unresolved tautology that undermines its validity.

… do we have a coherent theory of evolution? The firmly settled answer to this question is supposed to be “yes” …

I intend to argue in this book that the answer to my question might actually be “no.”

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