Moderator’s remark: this post is long enough to need a “more” tag. But the wordpress editor will only allow me to add that at the very beginning or the very end. So here it is at the very beginning.
Death has been on everyone’s mind at one time or another… It’s unavoidable…
Some are fascinated by death; mainly the possibility of better afterlife. Some, or the great majority of people, are frightened by it. It seems the unknown of after-death is one of the main factors causing many to tremble…
However, it turns out that Craig Venter, the pioneer of the human genome project and the supposed creator of artificial life, turned his attention and efforts toward decoding death… here
It seems obvious Venter believes that death is be caused by genetics; some genetic mutations that could be fixed and we could live forever, otherwise he wouldn’t be digging in the genome looking to fix the death code…
On Uncommon Descent, poster gpuccio has been discussing “functional information”. Most of gpuccio’s argument is a conventional “islands of function” argument. Not being very knowledgeable about biochemistry, I’ll happily leave that argument to others.
But I have been intrigued by gpuccio’s use of Functional Information, in particular gpuccio’s assertion that if we observe 500 bits of it, that this is a reliable indicator of Design, as here, about at the 11th sentence of point (a):
… the idea is that if we observe any object that exhibits complex functional information (for example, more than 500 bits of functional information ) for an explicitly defined function (whatever it is) we can safely infer design.
I wonder how this general method works. As far as I can see, it doesn’t work. There would be seem to be three possible ways of arguing for it, and in the end; two don’t work and one is just plain silly. Which of these is the basis for gpuccio’s statement? Let’s investigate …
- What separates humans from other organisms, and by how much? Dexterity (opposable thumb), Lifespan, Sociability, Speech, Bipedalism, Hairlessness, Body Size, and Diet, all separate humans from others, but none is more important and more off the chart than our Intelligence. And from these gifts, humans developed even more abilities; some natural like thick fur on demand, flight, excellent sensors, and powerful actuators; while others completely new like handling fire, writing, and life in the outer space. Continue reading
NAS president, April Furst, said today that evolution was a very good joke, but it’s gone on long enough. She stated, “It was an incredible setup, over a century and a half of teaching and ‘research’ into evolutionary theory, but we were waiting until people began to catch on to finally admit the joke. But with UD, and stellar minds like Kairosfocus, blowing our cover, we thought it was time to have a good laugh at the idea of Darwinism.”
There were some protests. Gull Able asked, well, what of the tree of life, why do organisms group into clades as they do? April responded, it’s a clear case of design for the sake of our ability to categorize and understand organisms. What order would you expect from the Designer, anyway? Something like the periodic table?”
Charl Atan tweeted April Furst, asking, “So who made the apparent transitionals, like Archaeopteryx and the various hominin fossils like Homo erctus?” Furst responded, “Haven’t you heard of prototypes?” Cen Sor said, “You were paid not to admit this secret. And anyway, why are later organisms made of strangely modified earlier parts and organs, like bat wings made out of mammalian hands?” April Furst was not abashed in the least, saying, “We were always going to admit the evolution hoax someday. And the Designer just happens to be a strong traditionalist, reworking organs incessantly while making little entirely new. The Designer wants kinds to be recognizable, after all.”
So there you have it, the evolutionary hoax is entirely exposed now. Have a good laugh, and get over it.
Regarding Kondrashov’s paper Why have we not died 100 times over?, an internet “pupil” of mine who goes by the handle of “nomenmeum” asked what is synergistic epistasis and soft selection. The definition of synergistic epistasis seems to be the major issue as I don’t see the term much in literature. I don’t know exactly what it means. Does synergistic epistasis entail a change in S-coefficients?
For example in Brenda Andrews’ double and triple knockout experiments with yeast, the corresponding single knockout experiments had little-to-no noticeable effects, but several double and triple knockouts would clearly have deleterious effect when their component individual single knockouts did not in isolation.
Below is Brenda Andrews’ description of her experiment which I mentioned at Sandwalk in connection with the ENCODE 2015 planning meeting (Larry Moran knew Dr. Andrews as a graduate student at his school):
William Basener and John Sanford have responded here to my post concerning whether R.A. Fisher’s Fundamental Theorem of Natural Selection is critical to work on the theoretical population genetics of the interaction between mutation and natural selection. (This reply by Basener and Sanford is also reposted here.) Continue reading
Here is an article on the issue of Dark DNA.
Dark DNA got its name from the cosmological phenomenon called Dark Matter – the undetectable 25% of the mass of the universe that scientists know exists because they can detect its effects…
Similarly Dark DNA has eluded the sequencing of the genomes and yet scientists know it must exist because they see its effects, such as in case of the sand rat…
Defending the validity and significance of the new theorem “Fundamental Theorem of Natural Selection With Mutations, Part II: Our Mutation-Selection Model
– Bill Basener and John Sanford
Joe Felsenstein and Michael Lynch (JF and ML) wrote a blog post, “Does Basener and Sanford’s model of mutation vs selection show that deleterious mutations are unstoppable?” Their post is thoughtful and we are glad to continue the dialogue. We previously wrote a first part of a response to their post, focusing on the impact of R. A. Fisher’s work. This is the second part of our response, focusing on the modelling and mathematics. Our paper can be found at: https://link.springer.com/article/10.1007/s00285-017-1190-x Continue reading
Natural Selection is described as “the differential survival and reproduction of individuals due to differences in phenotype”. To this, some add “blind, mindless, and purposeless environmental process” that nonetheless is imagined turning random genetic mutations into superior new features enhancing descendants’ survivability (fitness). Accumulation of these features supposedly turns one lifeform into another over time. Natural Selection seeks to explain the appearance of design in nature without appealing to a designer. Continue reading
– Bill Basener and John Sanford
Joe Felsenstein and Michael Lynch (JF and ML) wrote a blog post, “Does Basener and Sanford’s model of mutation vs selection show that deleterious mutations are unstoppable?” Their post is thoughtful and we are glad to continue the dialogue. This is the first part of a response to their post, focusing on the impact of R. A. Fisher’s work. Our paper can be found at: https://link.springer.com/article/10.1007/s00285-017-1190-x
First, a short background on our paper:
The primary thesis of our paper is that Fisher was wrong, in a fundamental way, in his belief that his theorem (“The Fundamental Theorem of Natural Selection”), implied the certainty of ongoing fitness increase. His claim was that mutations continually provide variance, and selection turns the variance into fitness increase. Central to his logic was that collectively; mutations have a net zero effect on fitness. While Fisher assumed mutations are collectively fitness-neutral, it is now known that the vast majority of mutations are deleterious. So mutations can potentially push fitness down – even in the presence of selection. Continue reading
Have you ever tried writing palindromes? How about writing phrases that can be read the same way in either direction? Here are some examples:
A man, a plan, a canal: Panama
Live not on evil
Was it a car or a cat I saw
These sentences were no doubt designed…
Can you imagine writing a book that can be read forwards and backwards containing 2 different stories that made sense? Not an easy task…
Watch the video and pay special attention to the following examples:
- Alternative splicing of RNA that produces multiple proteins from one gene
- Duons – Overlapping sequences that code for both protein expression and transcription factor binding sites simultaneously
- Dual coding genes in which one sequence is read in multiple frames to produce completely different protein
What is The Skeptical Zone, William Basener and John Sanford? Why should you care?
The Skeptical Zone is where a couple of distinguished biologists, Joe Felsenstein and Michael Lynch, have dignified a recently published article of yours with a response. That is all you need to know. If they had responded on the back of a cereal box instead, providing you with a form to clip, then it would have behooved you to clip the form, fill it out, and send it, along with a self-addressed, stamped envelope, to their post office box in Battle Creek, Michigan.
Of course, I am dating myself — and also you. That is just the point. You ought to know that, even as the computer enables studies that were impossible when Ronald Fisher dubbed a not-so-fundamental result of his the Fundamental Theorem of Natural Selection, it enables interaction with domain experts in ways that were impossible in Fisher’s time. We are well into the 21st Century, and no one under the age of 50 will find credible any reason you might offer for declining to engage Joe in this forum. You can ignore all of the riff-raff, myself included, and interact with the scientist who happened, about the time that your paper addressing Fisher’s theorem was published, to address the theorem in the 37th Fisher Memorial Lecture (via video link, I might add).
The prospects for resolving some points, and arriving at a degree of agreement, are much better in a modern exchange of comments than in an old-fashioned exchange of essays. One aspect of The Skeptical Zone makes it particularly appealing in discussion of mathematical models: you can enter stuff like \LaTeX between two dollar signs, and cause readers to see stuff like It’s a miracle!
by Joe Felsenstein and Michael Lynch
The blogs of creationists and advocates of ID have been abuzz lately about exciting new work by William Basener and John Sanford. In a peer-reviewed paper at Journal of Mathematical Biology, they have presented a mathematical model of mutation and natural selection in a haploid population, and they find in one realistic case that natural selection is unable to prevent the continual decline of fitness. This is presented as correcting R.A. Fisher’s 1930 “Fundamental Theorem of Natural Selection”, which they argue is the basis for all subsequent theory in population genetics. The blog postings on that will be found here, here, here, here, here, here, and here.
One of us (JF) has argued at The Skeptical Zone that they have misread the literature on population genetics. The theory of mutation and natural selection developed during the 1920s, was relatively fully developed before Fisher’s 1930 book. Fisher’s FTNS has been difficult to understand, and subsequent work has not depended on it. But that still leaves us with the issue of whether the B and S simulations show some startling behavior, with deleterious mutations seemingly unable to be prevented from continually rising in frequency. Let’s take a closer look at their simulations.
The blogs of creationists and ID advocates have been buzzing with the news that a new paper by William Basener and John Sanford, in Journal of Mathematical Biology, shows that natural selection will not lead to the increase of fitness. Some of the blog reports will be found here, here, here, here, here, and here. Sal Cordova has been quoting the paper at length in a comment here.
Basener and Sanford argue that the Fundamental Theorem of Natural Selection, put forward by R.A. Fisher in his book The Genetical Theory of Natural Selection in 1930, was the main foundation of the Modern Evolutionary Synthesis of the 1930s and 1940s. And that when mutation is added to the evolutionary forces modeled by that theorem, it can be shown that fitnesses typically decline rather than increase. They argue that Fisher expected increase of fitness to be typical (they call this Fisher’s Theorem”).
I’m going to argue here that this is a wrong reading of the history of theoretical population genetics and of the history of the Modern Synthesis. In a separate post, in a few days at Panda’s Thumb, I will argue that Basener and Sanford’s computer simulation has a fatal flaw that makes its behavior quite atypical of evolutionary processes.
Congratulations to our resident theoretical biologist of high renown, Joe Felsenstein, on his presentation, yesterday, of the 37th Fisher Memorial Lecture. [ETA: I’ll post a separate announcement of the video, when it is released.] Following are the details provided by the Fisher Memorial Trust (with a link added by me).
Title: Is there a more fundamental theorem of natural selection?
Abstract. R.A. Fisher’s Fundamental Theorem of Natural Selection has intrigued evolutionary biologists, who wondered whether it could be the basis of a general maximum principle for mean fitness of the population. Subsequent work by Warren Ewens, Anthony Edwards, and George Price showed that a reasonable version of the FTNS is true, but only if the quantity being increased by natural selection is not the mean fitness of the population but a more indirectly defined quantity. That leaves us in an unsatisfactory state. In spite of Fisher’s assertion that the theorem “hold[s] the supreme position among the biological sciences”, the Fundamental Theorem is, alas, not-so-fundamental. There is also the problem that the additive genetic variances involved do not change in an easily predictable way. Nevertheless, the FTNS is an early, and imaginative, attempt at formulating macro-scale laws from population-genetic principles. I will not attempt to revive the FTNS, but instead am trying to extend a 1978 model of mine, put forth in what may be my least-cited paper. This attempts to make a “toy” model of an evolving population in which we can bookkeep energy flows through an evolving population, and derive a long-term prediction for change of the energy content of the system. It may be possible to connect these predictions to the rate of increase of the adaptive information (the “specified information”) embodied in the genetic information in the organisms. The models are somewhat absurdly oversimple, but I argue that models like this at least can give us some results, which decades of more handwavy papers on the general connection between evolution, entropy, and information have not.
Merry Christmas, everyone!
Let’s have a serious discussion about phylogenetic systematics.
What are the assumptions, the methods, and the inferences that can be drawn from phylogenetic analysis.
For example, is there anything to the creationist claim that phylogenetic systematics assumes common ancestry and does it even matter?
I’ll be using a number of different references such as Molecular Evolution: A Phylogenetic Approach and Molecular Evolution and Phylogenetics.
This thread will not be password protected, but it will be protected by angels.
Darwinism is incomplete because it only takes account of matter and ignores spirit.
Evolution is a process of matter ascending and spirit descending. It is a process whereby physical substance goes through process that prepares it to accommodate the descending spirit. The continuity of living matter is sustained by hereditary and it takes on various forms due to adaptive radiation. But these forces come from the earth and they tie organisms to the environment and lead only to specialization. They take organisms down ever narrowing paths. The fossil record is a tableau of forms that are frozen in their specializations, evolutionary dead ends. These earthly forces radiate from the centre.
The spiritual forces work in the opposite direction drawing the living substance outwards, emancipating it from the earthly forces. Through these forces organisms separate out from the earth as a plant grows towards the sun. Emancipation is evident in such things as inner temperature control, freeing of the upper limbs to perform creative functions rather than them being used for locomotion or support and taking responsibility for care of offspring.
It is only in the human form that the self-conscious ego can occupy physical substance as a material individual. This is the place on earth where matter and spirit meet. In as much as each of us know ourselves, we know the spirit within. And this is only possible because our form has been prepared in such a way that it can accommodate our ego, the spirit within.
Darwin’s conforming of his theory to the old vera causa ideal shows that the theory of natural selection is probabilistic not because it introduces a probabilistic law or principle, but because it invokes a probabilistic cause, natural selection, definable as nonfortuitous differential reproduction of hereditary variants.