On The Origin of Species, read by Richard Dawkins (2007)

There is grandeur in this view of life, with its several powers having been originally breathed into a few forms or into one, and that while this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved.

These are the closing words of Darwin’s On the Origin of Species, read abridged in an audio recording by Richard Dawkins from 2007.

How should we read Darwin’s book today?

Should we read it as history? Is On The Origin of Species a Hopeful Monster of a theory lacking a mechanism and made irrelevant by more recent discoveries?

As politics? Is the book no more than a privileged English gentleman naturalist explaining interesting but unsupportable things to his own social class?

As science? Is it no more than a naturalist’s attempt to synthesise what was known or speculated from biology, geology and paleontology, physics and chemistry as it was known at the time?

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Denis Noble again….

Denis Noble has a new review out, in Experimental Physiology called Physiology is rocking the foundations of evolutionary biology.  Unfortunately the article itself is behind a paywall, but here is the abstract:

The ‘Modern Synthesis’ (Neo-Darwinism) is a mid-20th century gene-centric view of evolution, based on random mutations accumulating to produce gradual change through natural selection. Any role of physiological function in influencing genetic inheritance was excluded. The organism became a mere carrier of the real objects of selection, its genes. We now know that genetic change is far from random and often not gradual. Molecular genetics and genome sequencing have deconstructed this unnecessarily restrictive view of evolution in a way that reintroduces physiological function and interactions with the environment as factors influencing the speed and nature of inherited change. Acquired characteristics can be inherited, and in a few but growing number of cases that inheritance has now been shown to be robust for many generations. The 21st century can look forward to a new synthesis that will reintegrate physiology with evolutionary biology.

It’s a nice synthesis of the views he expresses in his book, The Music of Life, which I mentioned a previous post, Reductionism Redux , but he also lays out very clearly the ways in which four assumptions that have underlain much thinking in evolutionary biology since the “modern synthesis” (not so modern now), need to be revisited.

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Protein Space and Hoyle’s Fallacy – a response to vjtorley

‘vjtorley’ has honoured me with my very own OP at Uncommon Descent in response to my piece on Protein Space. I cannot, of course, respond over there (being so darned uncivil and all!), so I will put my response in this here bottle and hope that a favourable wind will drive it to vjt’s shores. It’s a bit long (and I’m sure not any the better for it…but I’m responding to vjt and his several sources … ! ;)).


“Build me a protein – no guidance allowed!”

The title is an apparent demand for a ‘proof of concept’, but it is beyond intelligence too at the moment, despite a working system we can reverse engineer (a luxury not available to Ye Olde Designer). Of course I haven’t solved the problem, which is why I haven’t dusted off a space on my piano for that Nobel Prize. But endless repetition of Hoyle’s Fallacy from multiple sources does not stop it being a fallacious argument.

Dr Torley bookends his post with a bit of misdirection. We get pictures of, respectively, a modern protein and a modern ribozyme. It has never been disputed that modern proteins and ribozymes are complex, and almost certainly not achievable in a single step. But

1) Is modern complexity relevant to abiogenesis?

2) Is modern complexity relevant to evolution?


Here are three more complex objects:

DESCRIPTION HERE

Circuit Board

DESCRIPTION HERE

Panda playing the flute

DESCRIPTION HERE

er … not yet in service!

 

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Is Darwinism a better explanation of life than Intelligent Design?

I recently bumped a post by keiths: Things That IDers Don’t Understand, Part 1 — Intelligent Design is not compatible with the evidence for common descent as it had come up in a recent discussion.  Vjtorley has responded on UD with a post called Is Darwinism a better explanation of life than Intelligent Design?

I’ve unbumped keiths’ post, as the thread was getting rather long, and in any case, it would be good to respond to vjtorley, who is, of course, very welcome to come over here in purpose.  I like Dr Torley, and do hope he will drop by, but in any case, the loudhailer seems to work reasonably well!

Feel free to continue the discussion that had been renewed on keiths’ post in this one (or on the old one if you like, using the link).

Dr Nim

It has struck me more than once that a lot of the confusion that accompanies discussions about stuff like consciousness and free will, and intelligent design, and teleology, even the explanatory filter, and the words “chance” and “random” arises from lack of clarity over the difference between decision-making and intention.  I think it’s useful to separate them, especially given the tendency for people, especially those making pro-ID arguments, but also those making ghost-in-the-machine consciousness or free will arguments, to regard “random” as meaning “unintentional”.  Informed decisions are not random.  Not all informed decisions involve intention.

This was my first computer:

It was called Dr Nim.  It was a computer game, but completely mechanical – no batteries required.  You had to beat Dr Nim, by not being the one left with the last marble, and you took turns with Dr Nim (the plastic board).  It was possible to beat Dr Nim, but usually Dr Nim won.

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Englishman in Istanbul proposes a thought experiment

at UD:

… I wonder if I could interest you in a little thought experiment, in the form of four simple questions:

1. Is it possible that we could discover an artifact on Mars that would prove the existence of extraterrestrials, without the presence or remains of the extraterrestrials themselves?

2. If yes, exactly what kind of artifact would suffice? Car? House? Writing? Complex device? Take your pick.

3. Explain rationally why the existence of this artifact would convince you of the existence of extraterrestrials.

4. Would that explanation be scientifically sound?

I would assert the following:

a. If you answer “Yes” to Question 4, then to deny ID is valid scientific methodology is nothing short of doublethink. You are saying that a rule that holds on Mars does not hold on Earth. How can that be right?

b. If you can answer Question 3 while answering “No” to Question 4, then you are admitting that methodological naturalism/materialism is not always a reliable source of truth.

c. If you support the idea that methodological naturalism/materialism is equivalent to rational thought, then you are obligated to answer “No” to Question 1.

 

Well, I can never resist a thought experiment, and this one seems quite enlightening….

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Journal club – Protein Space. Big, isn’t it?

Simplistic combinatorial analyses are an honoured tradition in anti-evolutionary circles. Hoyle’s is the archetype of the combinatorial approach, and he gets a whole fallacy named after him for his trouble. The approach will be familiar – a string of length n composed of v different kinds of subunit is one point in a permutation space containing vn points in total. The chance of hitting any given sequence in one step, such as the one you have selected as ‘target’, is the reciprocal of that number. Exponentiation being the powerful tool it is, it takes only a little work with a calculator to assess the permutations available to the biological polymers DNA and protein and come up with some implausibly large numbers and conclude that Life – and, if you are feeling bold, evolution – is impossible.

Dryden, Thomson and White of Edinburgh University’s Chemistry department argue in this 2008 paper that not only is the combinatorial space of the canonical 20 L-acids much smaller than simplistically assumed, but more surprisingly, that it is sufficiently small to have been explored completely during the history of life on earth. Continue reading

The Dialectic of Darwinism and Anti-Darwinism

I here present a number of theses, each of which deserves an independent argument in support of it, but which I think are both true and defensible:

(1) The resistance to Darwinism as expressed by creationism and by intelligent design largely arises from treating “Darwinism” as a scapegoat for the social ills produced by capitalism.  It has become commonplace among creationist and other anti-Darwinists to blame Darwinism for any and all of the following: eugenics, acceptance of homosexuality, sexual promiscuity, genocide, school shootings, abortion, and decline of ecclesiastical authority.

(2) Though the obsession with sexuality and anxiety about the ambiguity of embodiment are standard-fare among the religious far-right, my interest here lies in what it is about contemporary presentations of Darwinism that make it such a tempting target for these anxieties.

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Asymmetry

When I started this site, I had been struck by the remarkable symmetry between the objections raised by ID proponents to evolution, and the objections raised by ID opponents to ID – both “sides” seemed to think that the other side was motivated by fear of breaking ranks; fear of institutional expulsion; fear of facing up to the consequences of finding themselves mistaken; not understanding the other’s position adequately; blinkered by what they want, ideologically, to be true, etc.  Insulting characterisations are hurled freely in both directions. Those symmetries remain, as does the purpose of this site, which is to try to drill past those symmetrical prejudices to reach the mother-lode of genuine difference.

But two asymmetries now stand out to me:

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Belling the Cat

As Aesop didn’t actually say:

The Mice once called a meeting to decide on a plan to free themselves of their enemy, the Cat. At least they wished to find some way of knowing when she was coming, so they might have time to run away. Indeed, something had to be done, for they lived in such constant fear of her claws that they hardly dared stir from their dens by night or day. Many plans were discussed, but none of them was thought good enough. At last a very young Mouse got up and said: “I have a plan that seems very simple, but I know it will be successful. All we have to do is to hang a bell about the Cat’s neck. When we hear the bell ringing we will know immediately that our enemy is coming.” All the Mice were much surprised that they had not thought of such a plan before. But in the midst of the rejoicing over their good fortune, an old Mouse arose and said: “I will say that the plan of the young Mouse is very good. But let me ask one question: Who will bell the Cat?”

More heat than light seems to me to be generated by the demand for IDists to “define CSI” and the equations that are fired back in response. Nobody is disputing that we have plenty of equations.  Here is that bright young mouse, Dembski’s:

χ= –log2[10120 · φS(TP(T|H)]

The problem seems to me to lie in Belling the Cat.

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Andre’s questions

Andre poses some interesting questions to Nick Matzke. I thought I’d start a thread that might help him find some answers.  I’ll have first go :

Hi Nick

Yes please can we get a textbook on Macro-evolution’s facts!

I’ll make it easy for you;

1.) I want to see a step by step process of the evolution of the lung system.

Google Scholar: evolution of the lung sarcopterygian

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Searching for a search

Dembski seems to be back online again, with a couple of articles at ENV, one in response to a challenge by Joe Felsenstein for which we have a separate thread, and one billed as a “For Dummies” summary of his latest thinking, which I attempted to precis here. He is anxious to ensure that any critic of his theory is up to date with it, suggesting that he considers that his newest thinking is not rebutted by counter-arguments to his older work. He cites two papers (here and here) he has had published, co-authored with Robert Marks, and summarises the new approach thus:

So, what is the difference between the earlier work on conservation of information and the later? The earlier work on conservation of information focused on particular events that matched particular patterns (specifications) and that could be assigned probabilities below certain cutoffs. Conservation of information in this sense was logically equivalent to the design detection apparatus that I had first laid out in my book The Design Inference (Cambridge, 1998).

In the newer approach to conservation of information, the focus is not on drawing design inferences but on understanding search in general and how information facilitates successful search. The focus is therefore not so much on individual probabilities as on probability distributions and how they change as searches incorporate information. My universal probability bound of 1 in 10^150 (a perennial sticking point for Shallit and Felsenstein) therefore becomes irrelevant in the new form of conservation of information whereas in the earlier it was essential because there a certain probability threshold had to be attained before conservation of information could be said to apply. The new form is more powerful and conceptually elegant. Rather than lead to a design inference, it shows that accounting for the information required for successful search leads to a regress that only intensifies as one backtracks. It therefore suggests an ultimate source of information, which it can reasonably be argued is a designer. I explain all this in a nontechnical way in an article I posted at ENV a few months back titled “Conservation of Information Made Simple” (go here).

 

As far as I can see from his For Dummies version, as well as from his two published articles, he has reformulated his argument for ID thus:

Patterns that are unlikely to be found by a random search may be found by an informed search, but in that case, the information represented by the low probability of finding such a pattern by random search is now transferred to the low probability of finding the informed search strategy.  Therefore, while a given search strategy may well be able to find a pattern unlikely to be found by a random search, the kind of search strategy that can find it itself commensurably improbable i.e. unlikely to be found by random search.

Therefore, even if we can explain organisms by the existence of a fitness landscape with many smooth ramps to high fitness heights, we have are left with the even greater problem of explaining how such a fitness landscape came into being from random processes, and must infer Design.

I’d be grateful if a Dembski advocate could check that I have this right, remotely if you like, but better still, come here and correct me in person!

But if I’m right, and Dembski has changed his argument from saying that organisms must be designed because they cannot be found by blind search to saying that they can be found by evolution, but evolution itself cannot be found by blind search, then I ask those who are currently persuaded by this argument to consider the critique below.

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Dembski challenges Felsenstein

at ENV to get up to date on the Law of Conservation of Information:

So, what is the difference between the earlier work on conservation of information and the later? The earlier work on conservation of information focused on particular events that matched particular patterns (specifications) and that could be assigned probabilities below certain cutoffs. Conservation of information in this sense was logically equivalent to the design detection apparatus that I had first laid out in my book The Design Inference (Cambridge, 1998).

In the newer approach to conservation of information, the focus is not on drawing design inferences but on understanding search in general and how information facilitates successful search. The focus is therefore not so much on individual probabilities as on probability distributions and how they change as searches incorporate information. My universal probability bound of 1 in 10^150 (a perennial sticking point for Shallit and Felsenstein) therefore becomes irrelevant in the new form of conservation of information whereas in the earlier it was essential because there a certain probability threshold had to be attained before conservation of information could be said to apply. The new form is more powerful and conceptually elegant. Rather than lead to a design inference, it shows that accounting for the information required for successful search leads to a regress that only intensifies as one backtracks. It therefore suggests an ultimate source of information, which it can reasonably be argued is a designer. I explain all this in a nontechnical way in an article I posted at ENV a few months back titled “Conservation of Information Made Simple” (go here).

So what’s the take-home lesson? It is this: Stephen Meyer’s grasp of conservation of information is up to date. His 2009 book Signature in the Cell devoted several chapters to the research by Marks and me on conservation of information, which in 2009 had been accepted for publication in the technical journals but had yet to be actually published. Consequently, we can expect Meyer’s 2013 book Darwin’s Doubt to show full cognizance of the conservation of information as it exists currently. By contrast, Felsenstein betrays a thoroughgoing ignorance of this literature.

It seems to me that Dembski has still entirely missed the point of Felsenstein’s (and others’) critique of his “Law of Conservation of Information”.  But perhaps it’s worth tackling Dembski’s newer formulations here?  The Dembski-Marks published papers, or perhaps the For Dummies article at ENV he links to above.

(Link to previous discussion of Dembsi’s Specification paper here, now re-un-stickied)

Reductionism Redux

As I’ve mentioned, I’m a great fan of Denis Noble, and recommend his book, the Music of Life, but you can get the content pretty well in total in this video of a lecture:

Principle of Systems Biology illustrated using the Virtual Heart

and there’s other material on his site.

So I was interested to see Ann Gauger making a very similar set of points in this piece: Life, Purpose, Mind: Where the Machine Metaphor Fails.

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“Natural Selection’s [too limited] Reach”

I hadn’t realised that the Biologic Instute had a diary/blog.

February’s article is by Ann Gauger, although it consists largely of quotations from Douglas Axe, and is called Natural Selection’s Reach.

What continues to astonish me about ID proponents is just how ignorant they are of evolutionary theory.  Ann Gauger starts by setting out to address a reader’s query:

A reader wrote us recently to ask why natural selection can’t extract enough information from the fitness landscape to explain complex features.

Well, obviously I dispute the premise of the question, but assuming that the reader and Gauger share the view that natural selection’s “reach” is too limited to “explain complex features”, let’s see how Gauger explains her stance.  She starts by rightly saying that:

It all depends on what you think the fitness landscape looks like

and then lets Axe go on to explain further.  Unfortunately, Axe appears to think it looks like this:

with complex features situated on the high distant peaks, and natural selection only able to move a step at a time, and only upwards.

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Optimus reponds to Kantian Naturalist

Like kairosfocus, I thought this was an excellent defence of ID, and deserves a response from those of us who can no longer post at UD (a little additional formatting applied by me):

KN

It’s central to the ideological glue that holds together “the ID movement” that the following are all conflated:Darwin’s theories; neo-Darwinism; modern evolutionary theory; Epicurean materialistic metaphysics; Enlightenment-inspired secularism. (Maybe I’m missing one or two pieces of the puzzle.) In my judgment, a mind incapable of making the requisite distinctions hardly deserves to be taken seriously.

I think your analysis of the driving force behind ID is way off base. That’s not to say that persons who advocate ID (including myself) aren’t sometimes guilty of sloppy use of language, nor am I making the claim that the modern synthetic theory of evolution is synonymous with materialism or secularism. Having made that acknowledgement, though, it is demonstrably true that

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Douglas Axe

has an interview on youtube (well, I assume it’s an interview – only his responses are shown).  Here’s a transcript, with some commentary by me, and no doubt other comments will be forthcoming 🙂

In Darwins’ day we knew very little about cellular chemistry, for one thing, we knew very little about  metabolism, about how cells go about making the chemicals that they need to make the big, the big parts of living cells.  We now understand that in some detail, we also understand about the proteins that do the chemistry of life. These are called enzymes.  We understand how large these enzymes are.  We understand that they are encoded by genes, and we understand how that encoding takes place, that’s called the genetic code.  So, really, you put all that together, we now understand something about digitally encoded information, in cells, encoded in the genome, we understand why it’s there, to code proteins, and how the proteins function to do the chemistry of life.  And we also have the ability to measure, to some degree, how much information is there.

All true, and clearly stated.  No issue from me there.

If you put all that together, we know see something that looks very much like human designs where we use digitally encoded information to accomplish things

Well, maybe.  A little.  One huge difference is that biological “designs” are self-reproducing organisms, and so far human designs are resolutely non-self-reproducing.  In fact, the obvious answer to the alien who finds a watch on a heath, and wonders if it was designed or not, is: “well, does it reproduce?”  If yes, it is probably biological.  If no, it’s probably designed by a person. But I’ll grant Axe his digitality – yes, nucleotides are discrete, and yes, their sequence is determines results in the cell products that go to make cells into reproducing organisms (and reproducing cells within organisms, of course.)

But after this excellent, clearly well informed and well-articulated start, he then adds a comment of mind-boggling ignorance:

and we know that it’s impossible to get information on that scale through a chance process that Darwinism employed.

What?

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Barry Arrington Part II: questions from Phinehas

A very nice post by Barry at UD struck me as worth reposting here (as I can’t post there), inspired by Neil Rickert:

Phinehas asks Neil Rickert a fascinating question about the supposed direction of evolution.  Neil says he will address it in a separate thread, and I started this one for that purpose.  The rest of the post is Phenehas’ question to Neil:

@Neil I also appreciate the professional tone. I am a skeptic regarding what evolution can actually accomplish. In keeping with your demonstrated patience, I’d be grateful if you would give serious consideration to something that keeps tripping me up. I’ve often thought of natural selection as the heuristic to random mutations’ exhaustive search.

A path-finding algorithm can be aided in finding a path from point A to point B by using distance to B as a heuristic to narrow the search space. Without a heuristic, you are left to blind chance. It is said that evolution has no purpose or goal, so there is no point B. It is also claimed that evolution isn’t simply the result of blind chance, so a heuristic would seem to be required. Somehow, natural selection is supposed to address both of these concerns. Nature selects for fitness, we are told, so somehow we have a heuristic even without a point B.

But what is fitness? How does it work as a heuristic? How is it defined? Evidently, it is all about reproductive success. But how does one measure reproductive success? This is where things get fuzzy for me. Surely evolution is a story about the rise of more and more complex organisms. Isn’t this how the tree of life is laid out? Surely it is the complexity of highly developed organisms that evolution seeks to explain. Surely Mt. Improbable has man near its peak and bacteria near its base. But by what metric is man more successful at reproducing than bacteria? If I am a sponge somewhere between the two extremes, how is a step toward bacteria any less of a point B for me than a step toward man? Why should the fitness heuristic prefer a step upward in complexity toward man in any way whatsoever over a step downward in complexity toward bacteria?

It seems that, under the more obvious metrics for calculating reproductive success, bacteria are hard to beat. Even more, a rise in complexity, if anything, would appear to lead to less reproductive success and not more. So how can natural selection be any sort of heuristic for helping us climb Mt Improbable’s complexity when every simpler organism at the base of the mountain is at least as fit in passing on its genes as the more complex organisms near it’s peak? And without this heuristic, how are we not back to a blind, exhaustive search?

 

Excellent questions.