Happy New Year

To all TSZ Members and Readers!

The end of the year and the imminent arrival of the new decade made me wonder when exactly Dr Liddle set this blog up. I see it was in (or at least prior to) August, 2011. Lizzie put up her first opening post Where does information come from? here. You can tell it’s the first because the link is to “hello_world”, the example post that comes with the WordPress package. UD addicts may like to follow this link to exchanges between Lizzie and the charming Upright Biped that may have had some part in the birth of TSZ. So TSZ is well on the way to it’s first decade – a remarkable achievement considering Lizzie has not actively participated here for some years.

Then I mused how much material (over 1,300 opening posts, over a quarter of a million comments) has been buried under the scrolling over. Recently, I was reminded by a Vincent Torley post at Uncommon Descent from 2013 that popped up randomly as a blast-from-the-past of an excellent post here by Allan Miller, Journal club – Protein Space. Big, isn’t it?. Having just re-read it, it seems a shame to me that it lies buried deep in TSZ archives. There is also a follow-up article that is equally meaty (Vincent Torley’s acknowledgement). I then wondered whether some posts and threads here merit a bit of re-exposure. We can bring them to the top of the pile as a featured post for a few days to give an opportunity for further discussion in the light, for example, of further developments.

Does anyone else have a suggestion for a post or a comment that they think deserves more attention than it received first time around?

And wishing everyone a happy and prosperous New Year and decade!

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164 thoughts on “Happy New Year

  1. I lost a very close friend to the Germanic New Medicine because of her mother’s crazy and disgusting beliefs. They wouldn’t even give her pain killers when she was already agonizing. Brings tears to my eyes

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  2. Here is a reference for those who would like to see how 85% + cases of cancer can be explained as the metabolic disease:

    THE CANCER DRUG TEMOZOLOMIDE INCREASES DRIVER MUTATIONS IN BRAIN TUMORS
    The toxic alkylating agent Temozolomide (TMZ) is the most common chemotherapy drug used for managing malignant brain tumors and produces a slight increase in progression-free survival for patients (52). Recent studies show that TMZ increases driver mutations in the brain tumor tissue of treated patients (53). How is it possible that a drug, which increases driver mutations, could also improve progression-free survival? The findings make no sense in light of the SMT but could be linked to the MMT. For example, some of the adverse effects of TMZ include fatigue, nausea, vomiting, diarrhea, and loss of appetite (54). All of these adverse effects are indirect forms of calorie restriction that would lower blood glucose levels, thus targeting the Warburg effect and the dependency of tumors on glucose.

    https://www.crossfit.com/essentials/is-cancer-a-genetic-or-metabolic-disease-part-5

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  3. And: “NON-MUTAGENIC ORIGIN OF METASTATIC BEHAVIOR
    Recent studies from Brook Chernet and Michael Levin have shown that alterations in bioelectric membrane signaling can produce the metastatic behavior of Xenopus melanocytes in the absence of somatic mutations, which further suggests that the tumorigenic phenotype is not dependent on nuclear gene mutations (43,44). In other words, nuclear gene mutations alone are insufficient for producing tumors, whereas the tumorigenic phenotype can be produced in some cells without nuclear mutations.

    THE ABSENCE OF GENE MUTATIONS IN CANCER CELLS
    The SMT is based on the premise that nuclear gene mutations are responsible for the dysregulated division of cancer cells. Stuart Baker, however, has reviewed gene sequencing studies that failed to detect any pathogenic somatic mutations in several types of cancers (45). Michael Kiebish et al. also found no pathogenic mutations in mitochondrial DNA from five independently derived mouse brain tumors (46). Moreover, Donald Williams Parsons et al. could find no mutations in any of the three signaling systems of sample Br20P that was obtained from aggressive glioblastoma (47).

    CANCER DRIVER GENES FOUND IN NORMAL CELLS
    Recent studies show that normal cells in various tissues contain cancer driver genes. Inigo Martincorena and his team recently found large numbers of cancer driver genes in normal human skin (48,49). Indeed, the prevalence of NOTCH1 mutations in normal esophagus tissue was several times higher than in esophageal cancers. Somatic driver mutations found in brain tissue have been linked to psychiatric disorders rather than to cancer (50). These findings are concerning given that new immunotherapies could target driver mutations in normal cells as well as in tumor cells (48). Significant adverse effects involving inadvertent targeting of normal tissue cells have already been seen in some patients treated with immunotherapies (51).

    https://www.crossfit.com/essentials/is-cancer-a-genetic-or-metabolic-disease-part-5

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  4. ” Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
    Jhang SM1, Taylor BS5,6,11, Costello JF1.

    Abstract
    Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor. To explore this hypothesis, we sequenced the exomes of 23 initial low-grade gliomas and recurrent tumors resected from the same patients. In 43% of cases, at least half of the mutations in the initial tumor were undetected at recurrence, including driver mutations in TP53, ATRX, SMARCA4, and BRAF; this suggests that recurrent tumors are often seeded by cells derived from the initial tumor at a very early stage of their evolution. Notably, tumors from 6 of 10 patients treated with the chemotherapeutic drug temozolomide (TMZ) followed an alternative evolutionary path to high-grade glioma. At recurrence,
    these tumors were hypermutated and harbored ,driver mutations in the RB (retinoblastoma) and Akt-mTOR (mammalian target of rapamycin) pathways that bore the signature of TMZ-induced mutagenesis.

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  5. Hey, J-Mac, what are your thoughts regarding vaccines? Your kids got all their shots?

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  6. dazz:
    I lost a very close friend to the Germanic New Medicine because of her mother’s crazy and disgusting beliefs. They wouldn’t even give her pain killers when she was already agonizing. Brings tears to my eyes

    That is awful.

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  7. newton: That is awful.

    She was diagnosed with Hodgkin’s disease at a very early stage. Doctors gave her a 90% chance of making a full recovery but she had to start with chemo right away, which her mother refused, being the crazy piece of shit she is. She wouldn’t let me talk to her daughter and eventually took her to some shady clinical facility in Mexico to continue with her shark cartilage treatment there.

    “Dr.” Ryke Geer Hamer, the founder of the Germanic New Medicine, taught that cancer is caused by some traumatic event (and also that conventional medicine is an instrument that Jews use to exterminate whites, go figure) and apparently Hamer told her that the cause of her cancer was related to me and some other Spaniard friends of her (she was Swedish). I loved her to the bone, and it haunts me to think that she died in horrible pain believing something I did gave her cancer.

    What do you think, J-Mac? Are you prepared to do the same to your kids if (knock on wood) you find yourself in a similar situation?

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  8. dazz: She was diagnosed with Hodgkin’s disease at a very early stage. Doctors gave her a 90% chance of making a full recovery but she had to start with chemo right away, which her mother refused, being the crazy piece of shit she is. She wouldn’t let me talk to her daughter and eventually took her to some shady clinical facility in Mexico to continue with her shark cartilage treatment there.

    Just gets worse, was your friend a minor?

    “Dr.” Ryke Geer Hamer, the founder of the Germanic New Medicine, taught that cancer is caused by some traumatic event (and also that conventional medicine is an instrument that Jews use to exterminate whites, go figure)

    And a dollop of anti Semitism added to the insanity.

    and apparently Hamer told her that the cause of her cancer was related to me and some other Spaniard friends of her (she was Swedish). I loved her to the bone, and it haunts me to think that she died in horrible pain believing something I did gave her cancer.

    I am so sorry, she was sick and manipulated by awful people she trusted. It is not much comfort but the belief was not her’s but the product of coercion. You need to cherish the time you shared and be happy she no longer is in pain. And try to do what you can to make sure no one else suffers like she did at the hands of evil.

    What do you think, J-Mac? Are you prepared to do the same to your kids if (knock on wood) you find yourself in a similar situation?

    No sane person would, I am sure J-mac is just as horrified as everyone else. Sorry again for the loss of your friend

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  9. newton: Just gets worse, was your friend a minor?

    She was 20

    newton: I am so sorry, she was sick and manipulated by awful people she trusted. It is not much comfort but the belief was not her’s but the product of coercion. You need to cherish the time you shared and be happy she no longer is in pain. And try to do what you can to make sure no one else suffers like she did at the hands of evil.

    Yes, thank you so much.

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  10. One day, there will be show trials, once the field recognises True Genius …

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  11. A dear friend of mine has cancer. She posted stuff about some metabolic cure – avocado stones or something. I was deeply conflicted – how can you pour cold water on Hope? ‘Can’t hurt’, she said – which is OK as long as it’s not a replacement therapy.

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  12. dazz,

    This is upsetting and so unnecessary! To die due to one’s own beliefs is a personal choice but to inflict one’s own ideas on another that results in their death, that’s horrendous, repugnant and ought to be the subject of criminal proceedings. So sorry for your friend.

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  13. Alan Fox,

    Thank you, Alan. Much appreciated. I really hope this makes J-Mac come to his senses, and as Allan said, if you’re going to fall for some alternative medicine claptrap, at least don’t make it a replacement of mainstream science.

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