Functional information and the emergence of biocomplexity

Journal club time again 🙂

I like this paper: Functional information and the emergence of biocomplexity by Hazen et al, 2007 in PNAS, and which I hadn’t been aware of.

I’ve only had time to skim it so far, but as it seems to be an interesting treatment of the concepts variously referred to by ID proponents as CSI, dFCSI, etc, I thought it might be useful.  It is also written with reference to AVIDA.  Here is the abstract:

Complex emergent systems of many interacting components, including complex biological systems, have the potential to perform quantifiable functions. Accordingly, we define “functional information,” I(Ex ), as a measure of system complexity. For a given system and function, x (e.g., a folded RNA sequence that binds to GTP), and degree of function, Ex (e.g., the RNA–GTP binding energy), I(Ex ) = −log2[F(E x)], where F(Ex ) is the fraction of all possible configurations of the system that possess a degree of function ≥ Ex . Functional information, which we illustrate with letter sequences, artificial life, and biopolymers, thus represents the probability that an arbitrary configuration of a system will achieve a specific function to a specified degree. In each case we observe evidence for several distinct solutions with different maximum degrees of function, features that lead to steps in plots of information versus degree of function.

I thought it would be interesting to look at following the thread on Abel’s paper.  I’d certainly be interested in hearing what our ID contributors make of it 🙂

 

155 thoughts on “Functional information and the emergence of biocomplexity

  1. Your concession would be an acceptable alternative.

    Or, I can respond to whatever I feel like responding to whenever I feel like responding to it, whether or not you consider it an “acceptable” alternative.

  2. William J. Murray: Or, I can respond to whatever I feel like responding to whenever I feel like responding to it, whether or not you consider it an “acceptable” alternative.

    Very true. This is not UD and Elizabeth is not Barry, after all.

    Helloooo guano!

  3. What has evolved over hundreds of millions of years or maybe a billion years since such organisms were all that was on Earth are less fecund, less hardy, less “fit” organisms, by any non-tautological definition of the term.

    You continue to try imposing goals and targets on the process.

    Outside the laboratory, selection simply happens, It isn’t a deliberately structured algorithm. At some level, all causes are descriptions of before and after states. Gravity is a fine example of a cause that could be called tautological.

  4. WJM:

    The claim that a “fecund progeny” algorithm can produce a highly complex, interdependent, organized system of function by happy coincidence is magical thinking, especially when one considers that in perhaps 4.5 billion years of evolution it hasn’t produced anything more fecund, or more “progeny survivability” than existed very early on in that process, and all it has generated since are less fecund, less “progeny survivable” organisms – less fit by any non-tautological definition of the term.

    You saying God’s designs are getting worse?

    All that a bacterium can produce is two bacteria. That is its entire ‘fecundity function’. Its 4-billion-year success at that is indeed testament to the power of that way of doing things. Still, ultimately, it hits limits to growth, and the steady state average is limited to one surviving ‘offspring’ per ‘parent’.

    But multicellular organisms – by virtue of precisely that feature, multicellularity – can produce billions upon billions of ‘offspring’ – ie, gametes. That excess is filtered by the need to find a partner in a sexual species, and ultimately, brought back to an average of a half-share in each of two offspring per organism by environmental limits in a steady state population. Which is the same as the bacterium – after all that messing about, all the gametes in a present population end up generating an average of one copy each in the next (in a steady state population).

    The haploid genomes are neither more nor less fecund – they just generate intermediates that are one hell of a lot bigger and more complex. And one significant reason for that is sex.

    Evolution is running-to-stand-still. When a new allele arises that raises fitness (offspring production), it spreads until the entire population has it. The playing field has been levelled again – until another allele arises that raises (immediate) fitness. It is a mischaracterisation of the process to think that it means that modern organisms should be more fecund on the average than ancient ones – there are external limits, not least a world full of fecund organisms all playing the same game. A reading of Malthus might help there. Fecundity promotes variants within the population; it does not indefinitely increase the average fecundity of the population, in the presence of other populations.

  5. Joe Felsenstein: Look at it on the web. It can easily be found using Dembski+Felsenstein in a search engine.Note particularly the section on “Generating Specified Information” which gives a simple gene frequency example of natural selection getting you out further on a fitness scale — exactly the sort of thing that is also being called Functional Information. The example generates about 2 bits of it in 84 generations, and that can be repeated elsewhere in the genome.

    Gene frequency?

    You are starting with what needs to be explained in the first place.

    Geez it appears that you don’t even understand what ID says.

  6. You continue to try imposing goals and targets on the process.

    You continue to fundamentally misunderstand the difference between (1) claiming a target is prescribed by a process and (2) pointing at what a process is claimed to have achieved and using the term “target” to refer that structure and others categorically like it.

  7. William J. Murray: Or, I can respond to whatever I feel like responding to whenever I feel like responding to it, whether or not you consider it an “acceptable” alternative.

    Of course 🙂 I just said I’d be equally interested in a concession as in a rebuttal.

    You are more than welcome, of course to supply something completely different, or nothing at all.

    But “nothing at all” of course would be less interesting.

    So let’s just say I’d be interested in any response you care to offer 🙂

    But unfortunately I won’t be back to read it until Sunday. Have a good time, guys 🙂

    (And Joe G, please not a whole pile of guano for me to shift when I get back – my garden is grateful, but my back hurts ….)

  8. Joe G,

    Joe G: Gene frequency?

    You are starting with what needs to be explained in the first place.

    Geez it appears that you don’t even understand what ID says.

    William Dembski doesn’t understand it either? His proofs use a space of genotypes (which, as anyone who has taken my theoretical population genetics course must know, means that any population of genotypes from that space has gene frequencies).

  9. William J. Murray: Yet, over billions of years. what do we see arising – supposedly – from this evolutionary process? Less survivable, and less fecund organisms than, as the evidence indicates, we basically started with. Bacteria are extremely survivable, and extremely fecund. They might be the most hardy living organisms on earth; yet, that is – presumably – the kind of organisms we started with.

    What has evolved over hundreds of millions of years or maybe a billion years since such organisms were all that was on Earth are less fecund, less hardy, less “fit” organisms, by any non-tautological definition of the term. Organisms that are far more complex as organized systems, and as such can live in far fewer environments, and reproduce less and with much greater difficulty, and die much more quickly and easily due to environment.

    No, organisms are not “less fit”, in any sense that is relevant, although perhaps in senses that you consider tautological.

    Populations today are (to those of us who accept common descent) those that have an unbroken lineage to our earliest common ancestral population, and consist of enough individuals with sufficient fitness to pass on their genetic inheritance to their offspring that the population remains extant (not extinct).

    They are the populations, in other words, with genomes that have been supplied with variance, and honed by natural selection, in such a manner that they have fitted their bearers to environments that range from primordial seas to a vast range of alternatives, including environments consisting of other living populations.

    Our own population now numbers 7 billion, and has even ventured into environments beyond the earth itself.

    If your definition of “fitness” excludes that diversity of capacity to thrive as “fitness”, I respectfully submit that your definition may be too narrow 🙂

  10. Joe Felsenstein:
    Joe G,

    William Dembski doesn’t understand it either?His proofs use a space of genotypes (which, as anyone who has taken my theoretical population genetics course must know, means that any population of genotypes from that space has gene frequencies).

    Joe,

    ID is all about origins- how living organisms originated directly affects any subsequent evolution.

    Living organisms were designed then they were also designed to evolve/ evolved by design.

  11. Joe G: Living organisms were designed then they were also designed to evolve/ evolved by design.

    and how would we tell that from regular NDE?

  12. Elizabeth: Please do.Would you like to post an OP?

    I think that, given the statements here by ID supporters, I should make such a post. I’ll draft it and send it to you Sunday so it will be here when you get back. I hope serious commenters like William J. Murray will be available for that discussion. There are assertions being made here that natural selection cannot put Functional Information (or Specified Information) into the genome. These are mistaken. This forum seems a good place to get everyone to agree. If your email address has changed recently please email me.

    Thanks for the kind words about my paper. Many of its arguments are due to others but I worked long and hard on it, and read William Dembski’s works very carefully. I think it is the clearest explanation out there of why (the effectiveness of) natural selection has not been refuted. It is now almost 5 years old, yet pro-ID commenters keep repeating arguments that were shown wrong in that paper. So we need another go-round, I guess.

  13. Thanks! Joe F. If you register here, I can set your permissions to post under your own name. Off to Wales now, see you all Sunday 🙂

  14. Joe:

    Living organisms were designed then they were also designed to evolve/ evolved by design.

    If that evolutionary capacity, and this mysterious GA, were so poor that the designer had to keep coming back and undetectably fiddle with it, it’s not really ‘designed to evolve’, is it?

  15. There are assertions being made here that natural selection cannot put Functional Information (or Specified Information) into the genome. These are mistaken. This forum seems a good place to get everyone to agree. If your email address has changed recently please email me.

    Natural selection doesn’t put anything into the genome. It only removes stuff that has already appeared there.

  16. Rich: and how would we tell that from regular NDE?

    NDE doesn’t do anything- it can’t even be tested- no testable hypotheses.

  17. Allan Miller:
    Joe:If that evolutionary capacity, and this mysterious GA, were so poor that the designer had to keep coming back and undetectably fiddle with it, it’s not really ‘designed to evolve’, is it?

    Nice strawman…

  18. I, for one, look forward to Joe’s paper that demonstrates natural selection can actually do something…

  19. Joe Felsenstein: I think it is the clearest explanation out there of why (the effectiveness of) natural selection has not been refuted. It is now almost 5 years old, yet pro-ID commenters keep repeating arguments that were shown wrong in that paper. So we need another go-round, I guess.

    It’s not too hard to see why natural selection can increase the value of this mathematical expression whether it is called “functional information” or something else.

    If the “function” that a subset of assembly rearrangements is to perform has to be performed at a specified level or better (those specifications are set by the current environment, of course), then there will be a subset of that subset of assemblies that have a higher level of performance.

    All natural selection has to do is “up the ante” by raising the bar on performance. That will either reduce the size of the subset of assemblies that can do the job or it can simply set the bar so high that there will not be any rearrangements of the assembly that can get the job done at this level.

    Thus the negative of the logarithm of that fraction of the assemblies gets larger as the fraction gets smaller. That is simply a result of the way this mathematical expression is defined. It’s the name “functional information” that appears to be confusing ID/creationists.

    Note that this does not imply that the subsets of assemblies that do the job well are necessarily extremely complicated (however one wishes to quantify that). Complexity may be an inhibitor in doing a particular function that a simpler system can do much better.

    In fact, the best system for the job may be intermediate between extreme simplicity and extreme complexity. So natural selection does not necessarily select for some “awesome complexity.” The result may not even give the impression of being designed

  20. Natural selection doesn’t put anything into the genome. It only removes stuff that has already appeared there.

    That would only be true if information was made of DNA. So are you saying that information is made of molecules?

  21. Mike Elzinga: It’s not too hard to see why natural selection can increase the value of this mathematical expression whether it is called “functional information” or something else.

    If the “function” that a subset of assembly rearrangements is to perform has to be performed at a specified level or better (those specifications are set by the current environment, of course), then there will be a subset of that subset of assemblies that have a higher level of performance.

    All natural selection has to do is “up the ante” by raising the bar on performance.That will either reduce the size of the subset of assemblies that can do the job or it can simply set the bar so high that there will not be any rearrangements of the assembly that can get the job done at this level.

    Thus the negative of the logarithm of that fraction of the assemblies gets larger as the fraction gets smaller. That is simply a result of the way this mathematical expression is defined.It’s the name “functional information” that appears to be confusing ID/creationists.

    Note that this does not imply that the subsets of assemblies that do the job well are necessarily extremely complicated (however one wishes to quantify that).Complexity may be an inhibitor in doing a particular function that a simpler system can do much better.

    In fact, the best system for the job may be intermediate between extreme simplicity and extreme complexity.So natural selection does not necessarily select for some “awesome complexity.”The result may not even give the impression of being designed

    Except natural selection isn’t selection it is just a result. And a result that apparently cannot be differentiated from genetic drift.

  22. WJM:

    Natural selection doesn’t put anything into the genome. It only removes stuff that has already appeared there.

    I’m not sure where you get that from, but it is not true. Perhaps you are confusing what NS does to populations with what happens in individuals. Remember that “removing stuff that has already appeared there” can include getting rid of an ancestral sequence in the face of a new variant with elevated fitness. This is a process of “putting in something new” – concentration of one is automatically dilution of the other, in either direction.

    One needs to be clear about what is meant by ‘the genome’. Joe F was talking in terms of the ‘consensus’ genome of an entire species – cf The Human Genome [sense 1]. But another way of defining the genome is the entire hereditary information in a single cell [sense 2]. Evolution happens by a change in sense 2 being inherited such that there is an overall change in sense 1.

    Natural selection neither adds to nor subtracts from the genome sense 2 (individual cell). That task is performed by mutation and recombination. DNA can be added and removed, activated or disabled; ‘function’ can be changed for the better or worse (or not at all). NS isn’t doing it, but that does not affect the fact that the process can both ‘put in’ and ‘remove stuff’.

    Once a change has happened in one cell (genome sense 2), then to register a change in the species (genome sense 1), it has to become fixed in the population. Note that the change has already happened in the very first cell it arose in. It takes over the population by leaving descendants.

    The process of fixation in the species can include Natural Selection. That means that the new variant causes the fitness of its bearers to be greater on average than ‘wild-type’. In that sense, Natural Selection adds to/subtracts from the genome sense 2 (population) that which was added to/subtracted from the genome sense 1 (first bearer).

  23. JoeG: “Umm I have already read that paper- no evidence, just rhetoric.”

    Boy, THERE’S an exhaustive critique, if I’ve ever seen one!

  24. madbat089: JoeG: “Umm I have already read that paper- no evidence, just rhetoric.”

    Boy, THERE’S an exhaustive critique, if I’ve ever seen one!

    Perhaps JoeG is complaining about the lack of empirical data from actual organisms? Yeah, Joe Felsenstein wrote a merely theoretical refutation of Dembski’s completely theoretical argument… we’re missing the lab experiments, the field experiments, and the experimental replication of the entire history of life tracking every mutation nucleotide by nucleotide (and that experiment would have been designed, therefore proving ID). And balloon animals!

  25. madbat089:
    JoeG: “Umm I have already read that paper- no evidence, just rhetoric.”

    Boy, THERE’S an exhaustive critique, if I’ve ever seen one!

    What is there to critique?

    Please point me to the EVIDENCE which DEMONSTRATES that natural selection can construct things.

  26. Geoxus: Perhaps JoeG is complaining about the lack of empirical data from actual organisms? Yeah, Joe Felsenstein wrote a merely theoretical refutation of Dembski’s completely theoretical argument… we’re missing the lab experiments, the field experiments, and the experimental replication of the entire history of life tracking every mutation nucleotide by nucleotide (and that experiment would have been designed, therefore proving ID). And balloon animals!

    Don’t blame me because your position lacks supportingg data.

  27. joe g said:

    “Except natural selection isn’t selection it is just a result.”

    A result of what? And can there be a “result” if nothing happens?

    joe g said:

    “Please point me to the EVIDENCE which DEMONSTRATES that natural selection can construct things.”

    I don’t recall anyone saying that NS “can construct things”. You’re arguing with real scientists, joe. You should be more specific, and at least try to sound more sciency.

    Hey joe, please point me to the EVIDENCE which DEMONSTRATES that your imaginary god allah can construct things.

  28. Joe Felsenstein,

    Hello ID/Creationist here, I have just starting reading your paper and I believe I have stumbled across a possible glitch in your premise that would lead to an invalid conclusion. I’ll wait for Sunday to view the contents of your summary before posting my 2 cents.

  29. junkdnaforlife:
    Joe Felsenstein,

    Hello ID/Creationist here, I have just starting reading your paper and I believe I have stumbled across a possible glitch in your premise that would lead to an invalid conclusion. I’ll wait for Sunday to view the contents of your summary before posting my 2 cents.

    We can do that here too. The post I hope to make soon will mostly set up a specific genetic model and show that natural selection does put Functional Information into the genome. If you have found a glitch in the argument of my 2007 paper you might better mention it here unless it concerns that model.

    Thanks for being willing to actually discuss the argument of my paper. It is a refreshing contrast to absurd demands that I change the topic to the Origin Of Life, or to some sort of empirical evidence.

  30. Elizabeth:
    Thanks! Joe F.If you register here, I can set your permissions to post under your own name.Off to Wales now, see you all Sunday

    I have now registered. Enjoy Wales and its friendly people, who Flanders and Swann memorably said “sing much too loud, much too long, and too flat”.

  31. Joe Felsenstein: We can do that here too.The post I hope to make soon will mostly set up a specific genetic model and show that natural selection does put Functional Information into the genome.If you have found a glitch in the argument of my 2007 paper you might better mention it here unless it concerns that model.

    Thanks for being willing to actually discuss the argument of my paper.It is a refreshing contrast to absurd demands that I change the topic to the Origin Of Life, or to some sort of empirical evidence.

    Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

  32. Joe:

    ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Well … I can’t resist – why does this mean that there is anything wrong – anything at all – with evolutionary theory? That is, a process of successive mutation-fixations taking place since, giving rise to the pattern of Common descent that arose from their differential operation across reproductive barriers, plus IC, CSI, OMGJIAFA etc, while the designer suns himself on Omega 6 with a good book? Why did the designer have to do anything further, if life was ‘designed to evolve’ … ?

  33. Allan Miller:
    Joe:Well … I can’t resist – why does this mean that there is anything wrong – anything at all – with evolutionary theory? That is, a process of successive mutation-fixations taking place since, giving rise to the pattern of Common descent that arose from their differential operation across reproductive barriers, plus IC, CSI, OMGJIAFA etc, while the designer suns himself on Omega 6 with a good book? Why did the designer have to do anything further, if life was ‘designed to evolve’ … ?

    Well ID is not anti-evolution- and if the evolution is directed then it ain’t blind watchmaker evolution.

    And again if your position had any positive evidence we wouldn’t be having this discussion

  34. Well ID is not anti-evolution- and if the evolution is directed then it ain’t blind watchmaker evolution.

    And again if your position had any positive evidence we wouldn’t be having this discussion

    Jesus Christ, Joe, how many times have you posted that? Don’t you get bored?

    You say that ID is not anti-evolution, and then refuse to accept Word 1 from evolutionary theory. And positive evidence? Give me a break! Show me one of your freakin’ designing aliens and we wouldn’t be having this – ahem – ‘discussion’.

    But either way – evolution including Darwinian mechanisms or something unspecified arising from your ‘GA’ – I’ll simplify my question to this: do you think the designer continued to tinker with life after programming it at the OOL, or do you think the ‘GA’ was sufficient?

  35. Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    By the same token, Dembski doesn’t have anything with respect to science.

  36. Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Where’s your empirical evidence of allah, joe?

    Where’s your empirical evidence of ID?

    Where’s your empirical evidence of “CSI”?

    Where’s your empirical evidence of your assertions about genetic algorithms?

    Where’s your empirical evidence of your assertions about origins/creation?

    Where is the ‘science’ in anything that you assert?

  37. Joe G: Well if you don’t have any empirical evidence you don’t have anything wrt science.

    BTW ID is all about the OoL. As I said if living organisms were designed then they were also designed to evolve.

    Where’s your empirical evidence of allah, joe?

    Where’s your empirical evidence of ID?

    Where’s your empirical evidence of “CSI”?

    Where’s your empirical evidence of your assertions about genetic algorithms?

    Where’s your empirical evidence of your assertions about origins/creation?

    Where is the ‘science’ in anything that you assert?

  38. Geoxus: By the same token, Dembski doesn’t have anything with respect to science.

    Except ID has plenty of empirical evidence that agencies can produce CSI and IC.

  39. Allan Miller: Jesus Christ, Joe, how many times have you posted that? Don’t you get bored?

    You say that ID is not anti-evolution, and then refuse to accept Word 1 from evolutionary theory. And positive evidence? Give me a break! Show me one of your freakin’ designing aliens and we wouldn’t be having this – ahem – ‘discussion’.

    But either way – evolution including Darwinian mechanisms or something unspecified arising from your ‘GA’ – I’ll simplify my question to this: do you think the designer continued to tinker with life after programming it at the OOL, or do you think the ‘GA’ was sufficient?

    Allan- don’t blame me for your ignorance.

    Also I see you need proof of ID and that proves that you ain’t interested in science.

    GA was sufficient- as I said it all depends on those starting conditions.

  40. As dawkins and others have said- if living organisms were designed we would be looking at a totally different kind of biology- just as saying Stonehenge was designed turned a possible geological investigation into an archaeoloical investigation- totally different.

  41. Given that an algorithm may be defined as a list of instructions to perform a sequence of operations, some of which may be dependent upon the results of preceding operations,; whereabouts in the cell, Joe, is your GA – the list of instructions – stored?

    In the genome or elsewhere?,. If not in the genome, where exactly?

  42. damitall:
    Given that an algorithm may be defined as a list of instructions to perform a sequence of operations, some of which may be dependent upon the results of preceding operations,; whereabouts in the cell, Joe, is your GA – the list of instructions – stored?

    In the genome or elsewhere?,. If not in the genome, where exactly?

    In the cell- that is all I know at this time. I doubt it is in the DNA although the DNA can be a storge medium for instructions.

  43. Joe G: In the cell- that is all I know at this time. I doubt it is in the DNA although the DNA can be a storge medium for instructions.

    Joe, think that’s an incorrect use of the word “know”

    When are you coming over to the UK, Joe?. I could pick you up at Heathrow, we could be in Cambridge in just over the hour, and I’ll try and line up some top-flight geneticists and cell physiologists to talk to, and labs to visit – Cambridge is stuffed with ’em both within and outside the University.

    I’ll even try to line up some IDists, though they’re a bit thin on the ground in these parts

  44. That paper at the beginning of this thread might well be interesting without any slant on ID.
    Could we have a sensible discussion about what it implies without any ID types interfering?

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