During the recent debate with Gpuccio at one point he claimed was that it was my prior adoption of particular ideology or worldview that led me to exclude design as an explanation. Thus reducing our disagreement to a choice of worldviews. I am not sure I know what a worldview is – but scepticism falls far short of being an ideology. All it amounts to is the demand for strong evidence before believing anything. This is just an approach to evidence and is compatible with all sorts of beliefs about the nature of reality.
To take the particular issue of whether life is designed. Scepticism does not exclude design. It just asks that a design explanation is evaluated by the same standards as any other explanation. It is not sufficient that other explanations are considered to be inadequate. If you happen to believe in a designer with the appropriate powers and motivation then you may well accept that as the best explanation for life. If you happen to believe in a designer with evil motivations and sufficient power then that is a perfect explanation for natural disasters. But these are beliefs which need to be separately evaluated with their own evidence. You cannot use the fact that a designer is a good explanation for life as evidence for that designer.